:root {
    --bg-primary: #f8fafc;
    --bg-secondary: #ffffff;
    --bg-tertiary: #f1f5f9;
    --bg-card: #ffffff;
    --accent-primary: #0ea5e9;
    --accent-secondary: #0284c7;
    --accent-warm: #ef4444;
    --accent-blue: #06b6d4;
    --accent-purple: #8b5cf6;
    --accent-orange: #f97316;
    --accent-green: #10b981;
    --text-primary: #1e293b;
    --text-secondary: #64748b;
    --text-muted: #94a3b8;
    --border-subtle: rgba(0,0,0,0.08);
    --border-hover: rgba(0,0,0,0.15);
    --glass: rgba(255, 255, 255, 0.9);
    --shadow-sm: 0 1px 2px rgba(0,0,0,0.05);
    --shadow-md: 0 4px 12px rgba(0,0,0,0.08);
    --shadow-lg: 0 8px 24px rgba(0,0,0,0.12);
    --radius-sm: 6px;
    --radius-md: 10px;
    --radius-lg: 16px;
    --transition: all 0.2s ease;
}

* { margin: 0; padding: 0; box-sizing: border-box; }
html { scroll-behavior: smooth; }

body {
    font-family: 'DM Sans', -apple-system, sans-serif;
    background: var(--bg-primary);
    color: var(--text-primary);
    line-height: 1.6;
    min-height: 100vh;
}

/* Background Effects */
.bg-grid {
    position: fixed;
    top: 0; left: 0;
    width: 100%; height: 100%;
    background-image: 
        linear-gradient(rgba(14,165,233,0.03) 1px, transparent 1px),
        linear-gradient(90deg, rgba(14,165,233,0.03) 1px, transparent 1px);
    background-size: 50px 50px;
    pointer-events: none;
    z-index: 0;
}

.bg-gradient {
    position: fixed;
    top: 0; left: 0;
    width: 100%; height: 100%;
    background: 
        radial-gradient(ellipse 80% 50% at 50% -20%, rgba(14,165,233,0.15) 0%, transparent 50%),
        radial-gradient(ellipse 60% 40% at 100% 100%, rgba(139,92,246,0.08) 0%, transparent 50%);
    pointer-events: none;
    z-index: 0;
}

/* Header */
header {
    position: sticky;
    top: 0;
    z-index: 100;
    background: var(--glass);
    backdrop-filter: blur(12px);
    border-bottom: 1px solid var(--border-subtle);
    padding: 0.875rem 2rem;
    box-shadow: var(--shadow-sm);
}

.header-content {
    max-width: 1600px;
    margin: 0 auto;
    display: flex;
    align-items: center;
    justify-content: space-between;
    gap: 2rem;
}

.logo {
    display: flex;
    align-items: center;
    gap: 0.75rem;
}

.logo-icon {
    width: 40px; height: 40px;
    background: linear-gradient(135deg, var(--accent-primary), var(--accent-purple));
    border-radius: var(--radius-sm);
    display: flex;
    align-items: center;
    justify-content: center;
    font-family: 'Space Mono', monospace;
    font-weight: 700;
    font-size: 1rem;
    color: white;
    box-shadow: 0 2px 8px rgba(14,165,233,0.3);
}

.logo-text {
    font-family: 'Fraunces', serif;
    font-size: 1.4rem;
    font-weight: 500;
    letter-spacing: -0.02em;
    color: var(--text-primary);
}

.logo-text span { 
    background: linear-gradient(135deg, var(--accent-primary), var(--accent-purple));
    -webkit-background-clip: text;
    -webkit-text-fill-color: transparent;
    background-clip: text;
}

.header-nav {
    display: flex;
    align-items: center;
    gap: 1rem;
}

.nav-link {
    color: var(--text-secondary);
    text-decoration: none;
    font-size: 0.875rem;
    font-weight: 500;
    transition: var(--transition);
    padding: 0.5rem 1rem;
    border-radius: var(--radius-sm);
}

.nav-link:hover {
    color: var(--accent-primary);
    background: rgba(14,165,233,0.08);
}

/* Main Container */
main {
    position: relative;
    z-index: 1;
    max-width: 1600px;
    margin: 0 auto;
    padding: 1.5rem 2rem 3rem;
}

/* Hero Section */
.hero {
    text-align: center;
    padding: 2rem 0 2.5rem;
    animation: fadeInUp 0.6s ease-out;
}

@keyframes fadeInUp {
    from { opacity: 0; transform: translateY(16px); }
    to { opacity: 1; transform: translateY(0); }
}

.hero h1 {
    font-family: 'Fraunces', serif;
    font-size: clamp(1.5rem, 3.5vw, 2.25rem);
    font-weight: 500;
    letter-spacing: -0.02em;
    margin-bottom: 0.75rem;
    color: var(--text-primary);
    line-height: 1.3;
}

.hero p {
    color: var(--text-secondary);
    font-size: 1rem;
    max-width: 800px;
    margin: 0 auto;
    line-height: 1.7;
}

/* Stats Bar */
.stats-bar {
    display: grid;
    grid-template-columns: repeat(auto-fit, minmax(150px, 1fr));
    gap: 1rem;
    margin-bottom: 1.5rem;
    animation: fadeInUp 0.6s ease-out 0.1s both;
}

.stat-card {
    background: var(--bg-card);
    border: 1px solid var(--border-subtle);
    border-radius: var(--radius-md);
    padding: 1.25rem 1rem;
    text-align: center;
    transition: var(--transition);
    box-shadow: var(--shadow-sm);
}

.stat-card:hover {
    border-color: var(--accent-primary);
    box-shadow: var(--shadow-md), 0 0 0 3px rgba(14,165,233,0.1);
    transform: translateY(-2px);
}

.stat-value {
    font-family: 'Space Mono', monospace;
    font-size: 1.75rem;
    font-weight: 700;
    color: var(--accent-primary);
    display: block;
}

.stat-label {
    font-size: 0.7rem;
    color: var(--text-muted);
    text-transform: uppercase;
    letter-spacing: 0.08em;
    margin-top: 0.25rem;
    font-weight: 600;
}

/* Controls */
.controls {
    background: var(--bg-card);
    border: 1px solid var(--border-subtle);
    border-radius: var(--radius-lg);
    padding: 1.5rem;
    margin-bottom: 1.5rem;
    animation: fadeInUp 0.6s ease-out 0.2s both;
    box-shadow: var(--shadow-sm);
}

.controls-grid {
    display: grid;
    grid-template-columns: repeat(auto-fit, minmax(200px, 1fr));
    gap: 1rem;
}

.control-group {
    display: flex;
    flex-direction: column;
    gap: 0.5rem;
}

.control-label {
    font-size: 0.7rem;
    font-weight: 600;
    color: var(--text-muted);
    text-transform: uppercase;
    letter-spacing: 0.08em;
}

.search-input, select {
    width: 100%;
    padding: 0.75rem 1rem;
    background: var(--bg-tertiary);
    border: 1px solid var(--border-subtle);
    border-radius: var(--radius-md);
    color: var(--text-primary);
    font-size: 0.9rem;
    font-family: inherit;
    transition: var(--transition);
}

.search-wrapper { position: relative; }
.search-input { padding-left: 2.5rem; }

.search-icon {
    position: absolute;
    left: 0.875rem;
    top: 50%;
    transform: translateY(-50%);
    color: var(--text-muted);
    pointer-events: none;
}

.search-input:focus, select:focus {
    outline: none;
    border-color: var(--accent-primary);
    box-shadow: 0 0 0 3px rgba(14,165,233,0.15);
    background: var(--bg-secondary);
}

.search-input::placeholder { color: var(--text-muted); }

select {
    cursor: pointer;
    appearance: none;
    background-image: url("data:image/svg+xml,%3Csvg xmlns='http://www.w3.org/2000/svg' width='12' height='12' viewBox='0 0 12 12'%3E%3Cpath fill='%2394a3b8' d='M6 8L1 3h10z'/%3E%3C/svg%3E");
    background-repeat: no-repeat;
    background-position: right 1rem center;
}

/* Toggle Buttons */
.toggle-group {
    display: flex;
    flex-wrap: wrap;
    gap: 0.6rem;
    align-items: center;
}

.toggle-btn {
    display: flex;
    align-items: center;
    gap: 0.5rem;
    padding: 0.6rem 1rem;
    background: var(--bg-tertiary);
    border: 1px solid var(--border-subtle);
    border-radius: var(--radius-sm);
    color: var(--text-secondary);
    font-size: 0.85rem;
    font-weight: 500;
    cursor: pointer;
    transition: var(--transition);
}

.toggle-btn:hover {
    border-color: var(--accent-primary);
    color: var(--text-primary);
}

.toggle-btn.active {
    background: rgba(14,165,233,0.1);
    border-color: var(--accent-primary);
    color: var(--accent-primary);
}

.toggle-btn .checkmark {
    width: 16px; height: 16px;
    border: 2px solid currentColor;
    border-radius: 4px;
    display: flex;
    align-items: center;
    justify-content: center;
    transition: var(--transition);
}

.toggle-btn.active .checkmark {
    background: var(--accent-primary);
    border-color: var(--accent-primary);
}

.toggle-btn.active .checkmark::after {
    content: '✓';
    color: white;
    font-size: 0.65rem;
    font-weight: 700;
}

/* Table Container */
.table-container {
    background: var(--bg-card);
    border: 1px solid var(--border-subtle);
    border-radius: var(--radius-lg);
    overflow: hidden;
    animation: fadeInUp 0.6s ease-out 0.3s both;
    box-shadow: var(--shadow-md);
}

.table-header {
    display: flex;
    align-items: center;
    justify-content: space-between;
    padding: 1rem 1.5rem;
    border-bottom: 1px solid var(--border-subtle);
    background: var(--bg-tertiary);
    flex-wrap: wrap;
    gap: 0.75rem;
}

.table-title {
    font-size: 0.9rem;
    font-weight: 600;
    color: var(--text-secondary);
}

.table-title span {
    color: var(--accent-primary);
    font-family: 'Space Mono', monospace;
}

.table-actions {
    display: flex;
    gap: 0.5rem;
    position: relative;
}

.action-btn {
    display: flex;
    align-items: center;
    gap: 0.4rem;
    padding: 0.5rem 0.875rem;
    background: var(--bg-secondary);
    border: 1px solid var(--border-subtle);
    border-radius: var(--radius-sm);
    color: var(--text-secondary);
    font-size: 0.8rem;
    font-weight: 500;
    cursor: pointer;
    transition: var(--transition);
}

.action-btn:hover {
    border-color: var(--accent-primary);
    color: var(--accent-primary);
    background: rgba(14,165,233,0.05);
}

.table-wrapper {
    overflow-x: auto;
    max-height: 65vh;
    overflow-y: auto;
}

table {
    width: 100%;
    border-collapse: collapse;
    font-size: 0.85rem;
}

thead {
    position: sticky;
    top: 0;
    z-index: 10;
    background: var(--bg-tertiary);
}

th {
    padding: 0.875rem 1rem;
    text-align: left;
    font-weight: 600;
    color: var(--text-secondary);
    text-transform: uppercase;
    font-size: 0.7rem;
    letter-spacing: 0.06em;
    border-bottom: 2px solid var(--border-subtle);
    white-space: nowrap;
    cursor: pointer;
    transition: var(--transition);
    user-select: none;
}

th:hover {
    color: var(--accent-primary);
    background: rgba(14,165,233,0.05);
}

th.sorted { color: var(--accent-primary); }

th .sort-indicator {
    display: inline-block;
    margin-left: 0.4rem;
    opacity: 0.4;
}

th.sorted .sort-indicator { opacity: 1; }

td {
    padding: 0.875rem 1rem;
    border-bottom: 1px solid var(--border-subtle);
    color: var(--text-primary);
    vertical-align: middle;
}

tr:hover td { background: rgba(14,165,233,0.03); }

tr.cluster-center td {
    background: transparent;
}

tr.cluster-center td:first-child::before {
    display: none;
}

.rule-text {
    max-width: 320px;
    white-space: nowrap;
    overflow: hidden;
    text-overflow: ellipsis;
}

.rule-text:hover {
    white-space: normal;
    word-break: break-word;
}

/* Badges */
.badge {
    display: inline-block;
    padding: 0.25rem 0.625rem;
    border-radius: 999px;
    font-size: 0.7rem;
    font-weight: 600;
    text-transform: uppercase;
    letter-spacing: 0.03em;
}

.badge-cancer { 
    background: rgba(139,92,246,0.12); 
    color: var(--accent-purple); 
}

.badge-inclusion { 
    background: rgba(16,185,129,0.12); 
    color: var(--accent-green); 
}

.badge-exclusion { 
    background: rgba(239,68,68,0.12); 
    color: var(--accent-warm); 
}

.numeric {
    font-family: 'Space Mono', monospace;
    font-size: 0.8rem;
}

/* Exclusion Rate Visualization */
.exclusion-rate {
    display: flex;
    align-items: center;
    gap: 0.5rem;
}

.rate-bar {
    width: 60px;
    height: 6px;
    background: var(--bg-tertiary);
    border-radius: 3px;
    overflow: hidden;
}

.rate-fill {
    height: 100%;
    border-radius: 3px;
    transition: width 0.5s ease-out;
}

.rate-fill.low { background: var(--accent-green); }
.rate-fill.medium { background: var(--accent-orange); }
.rate-fill.high { background: var(--accent-warm); }

/* Pagination */
.pagination {
    display: flex;
    align-items: center;
    justify-content: space-between;
    padding: 1rem 1.5rem;
    border-top: 1px solid var(--border-subtle);
    background: var(--bg-tertiary);
    flex-wrap: wrap;
    gap: 0.75rem;
}

.pagination-info {
    font-size: 0.85rem;
    color: var(--text-muted);
}

.pagination-controls {
    display: flex;
    align-items: center;
    gap: 0.35rem;
}

.page-btn {
    width: 34px; height: 34px;
    display: flex;
    align-items: center;
    justify-content: center;
    background: var(--bg-secondary);
    border: 1px solid var(--border-subtle);
    border-radius: var(--radius-sm);
    color: var(--text-secondary);
    font-size: 0.85rem;
    cursor: pointer;
    transition: var(--transition);
}

.page-btn:hover:not(:disabled) {
    border-color: var(--accent-primary);
    color: var(--accent-primary);
}

.page-btn:disabled { opacity: 0.4; cursor: not-allowed; }

.page-btn.active {
    background: var(--accent-primary);
    border-color: var(--accent-primary);
    color: white;
}

/* Modal */
.modal-overlay {
    position: fixed;
    top: 0; left: 0;
    width: 100%; height: 100%;
    background: rgba(0,0,0,0.4);
    backdrop-filter: blur(4px);
    z-index: 1000;
    display: none;
    align-items: center;
    justify-content: center;
    padding: 2rem;
}

.modal-overlay.active { display: flex; }

.modal {
    background: var(--bg-card);
    border: 1px solid var(--border-subtle);
    border-radius: var(--radius-lg);
    width: 100%;
    max-width: 800px;
    max-height: 85vh;
    overflow: auto;
    animation: modalIn 0.25s ease-out;
    box-shadow: var(--shadow-lg);
}

@keyframes modalIn {
    from { opacity: 0; transform: scale(0.95) translateY(16px); }
    to { opacity: 1; transform: scale(1) translateY(0); }
}

.modal-header {
    display: flex;
    align-items: flex-start;
    justify-content: space-between;
    padding: 1.5rem;
    border-bottom: 1px solid var(--border-subtle);
    background: var(--bg-tertiary);
}

.modal-title {
    font-family: 'Fraunces', serif;
    font-size: 1.25rem;
    font-weight: 500;
    color: var(--text-primary);
}

.modal-close {
    width: 34px; height: 34px;
    display: flex;
    align-items: center;
    justify-content: center;
    background: var(--bg-secondary);
    border: 1px solid var(--border-subtle);
    border-radius: var(--radius-sm);
    color: var(--text-secondary);
    font-size: 1.25rem;
    cursor: pointer;
    transition: var(--transition);
}

.modal-close:hover {
    border-color: var(--accent-warm);
    color: var(--accent-warm);
    background: rgba(239,68,68,0.08);
}

.modal-body { padding: 1.5rem; }

.detail-grid {
    display: grid;
    grid-template-columns: repeat(auto-fit, minmax(170px, 1fr));
    gap: 0.875rem;
    margin-bottom: 1.5rem;
}

.detail-item {
    background: var(--bg-tertiary);
    padding: 1rem;
    border-radius: var(--radius-md);
    border: 1px solid var(--border-subtle);
}

.detail-label {
    font-size: 0.65rem;
    color: var(--text-muted);
    text-transform: uppercase;
    letter-spacing: 0.08em;
    margin-bottom: 0.25rem;
    font-weight: 600;
}

.detail-value {
    font-family: 'Space Mono', monospace;
    font-size: 1.1rem;
    color: var(--accent-primary);
    font-weight: 500;
}

/* Chart Container */
.chart-container {
    background: var(--bg-tertiary);
    border-radius: var(--radius-md);
    padding: 1.5rem;
    margin-top: 1rem;
    border: 1px solid var(--border-subtle);
}

.chart-title {
    font-size: 0.85rem;
    font-weight: 600;
    color: var(--text-secondary);
    margin-bottom: 1rem;
}

.bar-chart {
    display: flex;
    flex-direction: column;
    gap: 0.75rem;
}

.bar-item {
    display: grid;
    grid-template-columns: 110px 1fr 60px;
    gap: 1rem;
    align-items: center;
}

.bar-label {
    font-size: 0.8rem;
    color: var(--text-secondary);
    font-weight: 500;
}

.bar-track {
    height: 24px;
    background: var(--bg-secondary);
    border-radius: var(--radius-sm);
    overflow: hidden;
    border: 1px solid var(--border-subtle);
}

.bar-fill {
    height: 100%;
    border-radius: var(--radius-sm);
    transition: width 0.6s ease-out;
}

.bar-value {
    font-family: 'Space Mono', monospace;
    font-size: 0.8rem;
    color: var(--text-primary);
    text-align: right;
    font-weight: 500;
}

/* Column Toggle Panel */
.column-toggle-panel {
    display: none;
    position: absolute;
    top: 100%;
    right: 0;
    background: var(--bg-card);
    border: 1px solid var(--border-subtle);
    border-radius: var(--radius-md);
    padding: 1rem;
    min-width: 240px;
    max-height: 400px;
    overflow-y: auto;
    z-index: 50;
    box-shadow: var(--shadow-lg);
    margin-top: 0.5rem;
}

.column-toggle-panel.active { display: block; }

.column-toggle-item {
    display: flex;
    align-items: center;
    gap: 0.75rem;
    padding: 0.5rem;
    cursor: pointer;
    border-radius: var(--radius-sm);
    transition: var(--transition);
    font-size: 0.85rem;
    color: var(--text-primary);
}

.column-toggle-item:hover { background: var(--bg-tertiary); }
.column-toggle-item input { accent-color: var(--accent-primary); }

.column-group-title {
    font-size: 0.65rem;
    font-weight: 700;
    color: var(--text-muted);
    text-transform: uppercase;
    letter-spacing: 0.08em;
    padding: 0.75rem 0.5rem 0.35rem;
    border-top: 1px solid var(--border-subtle);
    margin-top: 0.5rem;
}

.column-group-title:first-child {
    border-top: none;
    margin-top: 0;
    padding-top: 0;
}

/* Loading State */
.loading {
    display: flex;
    flex-direction: column;
    align-items: center;
    justify-content: center;
    padding: 4rem;
    color: var(--text-muted);
    background: var(--bg-primary);
}

.spinner {
    width: 44px; height: 44px;
    border: 3px solid var(--border-subtle);
    border-top-color: var(--accent-primary);
    border-radius: 50%;
    animation: spin 0.8s linear infinite;
    margin-bottom: 1rem;
}

@keyframes spin { to { transform: rotate(360deg); } }

/* Scrollbar */
::-webkit-scrollbar { width: 8px; height: 8px; }
::-webkit-scrollbar-track { background: var(--bg-tertiary); }
::-webkit-scrollbar-thumb { background: var(--border-hover); border-radius: 4px; }
::-webkit-scrollbar-thumb:hover { background: var(--text-muted); }

/* Responsive */
@media (max-width: 768px) {
    header { padding: 0.75rem 1rem; }
    .header-content { flex-direction: column; gap: 0.75rem; }
    main { padding: 1rem; }
    .controls-grid { grid-template-columns: 1fr; }
    .pagination { flex-direction: column; gap: 0.75rem; }
    .hero h1 { font-size: 1.25rem; }
}